Selection of lead anti-OX40 and anti-4-1BB IS-Abs

One of the IACT partners (University of Southampton) has already generated >20 mouse anti-human 4-1BB and >20 mouse anti-human OX40 high affinity mAbs using conventional hybridoma technology. Several of these were shown to exhibit potent and reproducible agonist activity towards human T-cells in in vitro assays. Our path towards completion of the selection of our lead Abs will include additional functional assays and humanization of selected Abs.